Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in\nthe liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been\nused to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems\nused for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because\nthey can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocytederived\nchylomicrons, enhancing lymphatic drug transport. We believe that a full understanding of their contribution\nto intestinal drug translocation will lead to effective oral delivery with liposomal formulations.
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